We present a new determination of nPDFs from a global NLO QCD analysis of hard-scattering processes in lepton-nucleus and proton-nucleus collisions: nNNPDF3.0. In addition to available fixed-target data, we consider electrowea√k gauge boson, isolated photon, dijet, and D-meson production in proton-lead collisions at the LHC. As an application, we provide updated predictions for the ultra-high-energy (UHE) neutrino-nucleon cross-sections.